Exotic tropical fruits come and go as “super foods” in the spotlight, but for years broccoli has maintained a place on the A-list of healthy vegetables. Is it really justified, or is it just another example of nutrition hype? Do some of us benefit more than others?
No single vegetable can provide all the compounds found in plant foods that seem to play a role in reducing cancer risk. Broccoli – along with its other cruciferous vegetable “cousins” – really does seem to rank among the all-stars.
Many Exceptional Health Benefits
From Cruciferous Vegetables
Although broccoli literally brings a lot to the table, what I find especially intriguing is its impact as a cruciferous vegetable. This is a larger family of vegetables than many people realize, including cabbage, Brussels sprouts and cauliflower, and also bok choy, collard greens, kale, rapini, radishes, and more. When the vegetable cells are disrupted by chewing or chopping, an enzyme is released that converts the inactive glucosinolate compounds they contain to isothiocyanate and indole compounds that seem to have significant anti-cancer effects.
In cell studies and animal research, these compounds protect us from carcinogens by inhibiting enzymes that activate carcinogens and stimulating enzymes that detoxify them; decrease the inflammation that creates a pro-cancer environment within the body; turn on tumor suppressor genes that slow cell growth so that cell damage can be repaired and stimulate a process called apoptosis in which damaged cells self-destruct; decrease growth factors necessary for cancer cells to be able to spread; may also shift estrogen metabolism to favor a weaker, less cancer-promoting form.
Some questions people often ask about broccoli and other cruciferous vegetables are:
Q: Most of the studies showing benefit are lab studies. Does human data support a benefit?
A: Population studies do link greater consumption of cruciferous vegetables with lower risk of lung, colorectal, stomach, breast, prostate, and other cancers, although not consistently.
One year-long small intervention trial showed that men who ate 14 ounces of broccoli a week showed changes in insulin and growth factor signaling that would be expected to be cancer-protective.
Yet in one study, although total cruciferous vegetable consumption was not strongly linked to risk of breast cancer, women estimated to consume the largest amounts of isothiocyanate compounds showed an 18 percent lower risk of breast cancer, and a 32 percent lower risk of postmenopausal breast cancer. In the same group of Chinese women, when researchers assessed exposure to cruciferous vegetables by urinary excretion of compounds that form as the body metabolizes the active protective phytochemical, women who excreted the most later developed only half as much breast cancer as women who excreted the least.
Q: Why do the findings from human studies seem so inconsistent?
A: Isothiocyanate compounds from broccoli and other cruciferous vegetables come in a variety of forms. We don’t know how they may differ in effects.
Even if they eat the same amount of broccoli or total cruciferous vegetables, people will vary in the amount of isothiocyanates they get based on how much they chew the vegetable (exposing more of it to the enzyme that breaks down the inactive glucosinolates into the active compounds) and the particular types of bacteria in their gut (which also break down the inactive compounds to the active forms).
Genetic differences make some people metabolize and eliminate the active compounds from the body sooner than others, leaving them with less time exposed to their protection. In one study, among women with particular forms of genes that control how cruciferous compounds are metabolized, those with highest levels of isothiocyanate compounds in their urine showed a 50 percent lower risk of colorectal cancer than those with lowest levels of the compounds. Other women did not show protection.
Q: Does it matter if I eat cruciferous vegetables like broccoli and cabbage raw or cooked?
A: Cooking, even briefly blanching the vegetables before freezing, inactivates the enzyme that converts the inactive glucosinolates to active compounds. Studies show that people get more isothiocyanates from raw rather than cooked forms. That doesn’t mean you get nothing from cooked forms, however; those friendly gut bacteria do help break down the glucosinolates to provide protective isothiocyanates.
Glucosinolates are water-soluble compounds that may leach out into cooking water. Boiling cruciferous vegetables from 9 to15 minutes resulted in 18 to 59 percent decreases in the total glucosinolate content of cruciferous vegetables. So when you cook these vegetables, cook lightly to crisp-tender in methods that use little or no water, such as steaming or microwaving, to reduce glucosinolate losses.
Keep in mind that there’s more to broccoli than its glucosinolate compounds. Like many other dark green vegetables, it’s loaded with beta-carotene, which provides antioxidant protection to our DNA and promotes cell-to-cell communication that helps control cell growth; vitamin C to provide further antioxidant power; folate, a B vitamin that helps maintain healthy DNA and keep cancer-promoting genes “turned off”; and magnesium, which seems to keep insulin functioning properly, important to reduce risk of type 2 diabetes and probably cancer, too.
Some of us may get more benefit from cruciferous vegetables than others, but for all of us they are a choice that makes sense to include regularly as part of a wide variety of other vegetables and fruits.
Let’s talk: What are your favorite ways to prepare broccoli and other cruciferous vegetables? If you have children or others who have trouble with the slightly bitter flavor, how have you overcome it?
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Karen Collins, MS, RD, CDN is a Registered Dietitian who promotes healthy eating as a syndicated nutrition news columnist, speaker and consultant, bringing special expertise in cancer prevention and how it fits within overall wellness efforts. Karen can be contacted about speaking engagements at firstname.lastname@example.org. For more information, please visit http://www.karencollinsnutrition.com
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